Exercise Three: The Reversal Pote...

Get Started and make sure initial conditions are correct

Type runXoltolRun in the Matlab command window.
Select Exercise Three button.
That's it, nothing else.
When the simulation pops up, you'll use the xolotl puppeteer to control the simulation.

Please complete Exercise Three:

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In this exercise, xolotl automatically injects enough positive current to generate an action potential in the recorded neuron.

Find xolotl's puppeteer. It's a pop-up menu called xolotl::manipulate. Once found, go to the Reversal Potentials tab on the puppeteer. Therein, you'll find the following controllable sliders:

neuron.NaV.E
- This slider controls the reversal potential for sodium.
neuron.Kd.E
- This slider controls the reversal potential for potassium.

Questions:

1. What is the initial value of NaV.E?

2. What is the initial value of Kd.E?

3. Describe what is meant by "reversal potential". Refer to the values you provided in Questsions 1 & 2.

5. Slide the reversal potential for potassium to approximately -50 mV. What happened?

6. Hit the reset button on the puppeteer. Move the sliders to achieve the shortest action potential (in peak amplitude). What do you have to do to generate a short action potential? Explain your answer.

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